In vitro tests with fresh cigarette smoke - Effects of charcoal filters on whole smoke and vapour phase mutagenicity and genotoxicity
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چکیده
In vitro analysis of fresh smoke is an important part of cigarette testing because the exposure methods employed may reflect human smoke exposure. Whole smoke is a dynamic system and has to be handled accordingly. In a few seconds smoke changes its properties. Therefore, the period of time until the smoke is in contact with cells has to be kept as short as possible. The same preconditions need to be considered for the vapour phase. For realistic assessment and comparison of biological effects of whole smoke and its vapour phase the conditions of the tests have to be the same.
منابع مشابه
Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter.
A novel carbon filter has been developed which primarily reduces the amount of certain vapor phase constituents of tobacco smoke with greater efficiency than the charcoal filters of cigarettes currently in the market. In vitro indicators of genotoxic and cytotoxic potential were used to compare the cigarette smoke condensate (particulate phase) or whole cigarette smoke (vapor phase and particul...
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